一：复合SERS基底的设计与制备

利用多孔材料包括MOFs/COFs/HOFs、PS、SiO2作为纳米载体结合贵金属纳米颗粒构建高效的SERS基底

二：生物传感器的构建与设计

利用DNA适体或者抗体构建超灵敏SERS与电化学传感器用于污染物或者生物标志物的检测

三：多重DNA放大技术的设计与应用

设计目标物诱导多重DNA放大技术以及构建DNA框架材料

项目：

四川省自然科学基金青年基金项目，在研，主持

集料亚甲蓝值检测技术开发服务，在研，主持

泸县太伏火腿肉中抗生素检测技术开发服务，在研，主持

食品及农产品中危害残留物快速检测技术四川省青年科技创新研究团队-四川省科技计划项目专项资金，在研，参与

学术论文：

[1] Yi He*, Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Yao Liu, Mengjun Wang*. Efficient 2D HOF@Au SERS Substrates Synergized with the G‑quadruplex Network-Based Catalytic Amplification Strategy for Low-Background Trimode Detection of Lomefloxacin. Analytical Chemistry, 2025, 97, 48, 26971–26981.（中科院一区，IF = 6.7，自然指数期刊）

[2] Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Yao Liu, Yi He*. Efficient SERS Substrate HOF@Au in Conjunction with DNAzyme-Mediated DNA Walker as a Signal Amplifier for the Ultrasensitive Detection of Lomefloxacin. Analytical Chemistry, 2025, 97, 3180−3189.（中科院一区，IF = 6.7，自然指数期刊，高被引）

[3] Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Yao Liu, Xiaojun Luo*, Yi He*. Uniform 3D SERS substrate SiO2@AuAg collaborate with target-mediated DNA network structure as a signal amplifier for ultrasensitive detection of miRNA-21. Biosensors and Bioelectronics, 2025, 288, 117777.（中科院一区，IF = 10.5）

[4] Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Yao Liu, Ke Lei, Mengjun Wang*, Yi He*. Au-Ag alloy nanourchins as a highly efficient SERS tag synergistically with MOF@Au for the ultrasensitive detection of oxytetracycline. Journal of Colloid and Interface Science, 2025, 695, 137840.（中科院一区，IF = 9.7）

[5] Xiaoyu Yang, Shunbi Xie*, Weifen Wu, Jingwen Liu, Manjun Liao, Runzi Zhang, Yao Liu, Mengjun Wang*, Yi He*. Core-shell structure and twin-cone morphology of Au@Ag@HOF with efficient adsorption capability and high SERS enhancement efficiency for sensitive detection of bisphenol compounds in food. Food Chemistry, 2025, 495, 146522.（中科院一区，IF = 9.8）

[6] Yao Liu, Runzi Zhang, Xiaoyu Yang, Li Tang, Bing Shao, Yi He*, Xiao Yang*. Highly efficient catalytic hydrogen bond organic frameworks (HOFs)@HRP integrated with bowl-shaped organic SERS substrates for ultrasensitive detection of BPS.Food Chemistry, 2025, 500, 147440.（中科院一区，IF = 9.8）

[7] Xiaoyu Yang, Dan Zhou, Xin Yang, Bo Wu, Jiaxin Xie, Runzi Zhang, Yao Liu, Yi He*. A colorimetric/SERS dual-channel sensor based on multifunctional Co3O4@Ag NFs with photocatalytic signal amplification for ultrasensitive detection of diacetyl in food.Food Chemistry: X,2025, 31, 103002.（中科院一区，IF = 8.2）

[8] Yi He*, Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Yao Liu. An intelligent hydrogel detection platform based on colorimetric and SERS techniques for real-time and sensitive detection of kanamycin. Talanta, 2025, 294, 128246.（中科院二区，IF = 6.1）

[9] Yi He*, Runzi Zhang, Shunbi Xie*, Xiang He, Xioayu Yang, Yao Liu, Mengjun Wang*. A triple-mode strategy for ultrasensitive and accurate point-of-care detection of glyphosate based on the carved bimetallic prussian blue nanozyme and gold polyhedra. Journal of Food Composition and Analysis, 2025, 144, 107661.（中科院二区，IF = 4.6）

[10] Yi He*, Xiaoyu Yang, Shunbi Xie, Runzi Zhang, Yao Liu, Mengjun Wang*. Efficient SERS substrate HOF@Au synergistically CHA-mediated double-end DNA walker as high-efficient signal amplification strategy to achieve ultra-sensitive detection of roxithromycin. Microchemical Journal, 2025, 217, 115081.（中科院二区，IF = 5.1）

[11] Runzi Zhang, Shunbi Xie*, Xiaoyu Yang, Youlin Tang, Jingwen Liu, Manjun Liao, Mengjun Wang*, Yi He*. A SERS and colorimetric dual‑mode biosensor based on stimulus‑responsive DNA/MOF‑bound bimetallic nanozyme for the ultrasensitive detection of chloramphenicol in food. Microchimica Acta, 2025, 192, 62.（中科院二区，IF = 5.3，高被引）

[12] Runzi Zhang, Shunbi Xie*, Youlin Tang, Xiang He, Xiaoyu Yang, Yao Liu, Mengjun Wang*, Yi He*. Dual-catalytic hairpin amplification strategy as a highly efficient signal amplifier cooperative with COF@Au for ultrasensitive SERS detection of miRNA-21. Analytica Chimica Acta, 2025, 1369, 344361.（中科院二区，IF = 6.0）

[13] Runzi Zhang, Lian Zhang, Shunbi Xie*, Xiaoyu Yang, Yao Liu, Mengjun Wang*, Yi He*. A simple and rapid preparation of Au-Ag alloy nanourchins flexible membrane for ultrasensitive SERS detection of microplastics in water environment. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 341, 126451.（中科院二区，IF = 4.6）

[14] Xiaoyu Yang, Shunbi Xie*, Runzi Zhang, Yao Liu, Weifen Wu, Yi He*. An efficient SERS detection platform based on roseate petal homochiral nanogold (Au RHNs) as substrate for sensitive detection of plastics in environmental water samples. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 329, 125642.（中科院二区，IF = 4.6）

[15] Yao Liu, Runzi Zhang, Xiaoyu Yang, Yi He*, Xiao Yang*. An ultrasensitive SERS biosensor based on porous ZIF-8-encapsulated silver nanoflowers coordinated with host-gest recognition amplification strategy for the detection of bisphenol S. Microchemical Journal, 2025, 215, 114400.（中科院二区，IF = 5.1）

[16] Yao Liu, Runzi Zhang, Xiaoyu Yang, Yi He*, Xiao Yang*. Gold nanoparticle-decorated hydrogen-bonded organic frameworks (HOFs@Au) as efficient SERS substrates and photocatalytic tools for ultrasensitive detection and degradation of bisphenol contaminants. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 346, 126890.（中科院二区，IF = 4.6）

承担本科生分析化学、分析化学实验等教学工作。